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Facoltà di Scienze Agrarie e Alimentari Università degli Studi di Milano
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Probiotic microorganisms: biotechnology and applications
Code: G-014-
Teacher:  Simone Domenico Guglielmetti
Year:   
Term: 
CFU: 
CFU subdivision: Lectures: 4
Basic aims:  The course goals comprise the acquisition of knowledge on probiotic microorganisms (taxonomy and metabolism), the mechanisms underlying the interaction with the human host physiology and the research strategies adopted for their study. Finally, this course will complain the learning of the legislation in force and the technological aspects connected to probiotics.
Acquired skills:  At the end of this course, the student should have the ability to critically evaluate probiotic products, from the microbiological and technological point of view. Furthermore, the student should be able to determine the proper criteria for the selection of new potential probiotic microorganisms and for the scientific assessment of their efficacy. Finally, the student should have the skill to design a suitable product formulation in function of a specific application, in accordance with the legislation in force.
Course contents:  This course summarizes the modern interpretation of the probiotic approach, analyzed from the viewpoint of the scientific research. Industrial and legislative aspects will be also discussed.
Program:  The relationship between microorganisms and humans is inescapable, extending from Koch’s (one microbe, one disease) to Metchnikoff’s (lactic germs to prolong life) prospective. Microbes create a deep interaction and a thin equilibrium with their host, the perturbation of which can bring from mutualism to disease. Is it possible to modulate these interactions exogenously and in a controlled way in order to improve health? The drastic expansion of the probiotic market seems to suggest that many people believe that it is possible. This course summarizes the modern interpretation of the probiotic approach, analyzed from the viewpoint of the scientific research. Industrial and legislative aspects are also discussed. Program - The human/microbiota ‘superorganism’ and the human microbiome project - The role of the human intestinal microbiota (deepening: gut microbiota in obesity) - The origin of the probiotic approach - Probitics today: 2002 WHO/FAO guidelines - Probiotic microorganisms (deepening: bifidobacteria and their metabolism) - Health promoting activities of probiotics (deepening: the immunomodulatory molecules of Bifidobacterium bifidum) - Limitations and risks associated to probiotics (deepening: the case of probiotics in pancreatitis) - The probiotic market and the regulatory scenario in Europe today
Prerequisites:  Info not available
Preparatory instructions:  Biochemistry, General Microbiology
Learning materials:  Info not available
Other info:  Oral
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